Glutathione Deficiency Symptoms & Dosage for Whitening, Children-How to take

Did you know that reduced glutathione levels or deficiency altogether poses greater risk to your body? Your body immune system becomes weak making it susceptible to chronic illness. Explore more on the causes, symptoms of inadequate glutathione and the correct dosage for children and skin whitening.

Glutathione Deficiency, Causes, Symptoms & Test

Glutathione Deficiency

Glutathione deficiency is a disorder that prevents the production of glutathione molecule in the body. A reduction in glutathione levels makes the body unable to perform its important functions. A study shows that reduced levels of glutathione are caused by a lifestyle that in effect depletes glutathione.

Glutathione deficiency leads to:

  • Increase in the oxidative stress
  • Inability of the liver to effectively detoxify wastes and toxins.
  • toxins, free radicals and heavy metals such as mercury tend to build up in the body.
  • Inability of the to repair DNA ,proteins and other important cellular components
  • the body immune system becomes weak hence chronic illness find their way in.
  • reduced oxygen supply and nutrients resulting from destruction of red blood cells.

All these processes directly affects the state of immune system hence becoming the major cause of chronic illness such as kidney failure, liver disease ,cancer ,Parkinson’s disease etc.

Low glutathione could also mean that the prescribed treatment, instead of helping may actually worsen the condition since the drugs cause depletion of glutathione even further.

Documented research has shown that almost all chronic conditions are characterized by glutathione deficiency: HIV/AIDS, Alzheimer’s, asthma, all cancer, macular degeneration, chronic fatigue syndrome, diabetes, autoimmune disorders, liver diseases, lungs, heart, and digestive system, Parkinson’s disorders, tumors, autism, and many more. Non- chronic conditions include: burns, physical trauma, and any type of surgery.

Glutathione deficiency can be classified into three types: mild, moderate and severe.

Individuals who experience mild glutathione deficiency usually results in the destruction of red blood cells (hemolytic anemia) .In addition, affected individuals release large amounts of a compound called 5-oxoproline in their urine.

Moderate glutathione levels individuals may experience symptoms beginning shortly after birth including hemolytic anemia, 5-oxoprolinuria and increased acidity in the blood and tissues.

on the other hand, Individuals with severe glutathione levels experience neurological symptoms such as seizures; general slowing down of the physical reactions, movements and speech (psychomotor retardation), intellectual disability and loss of coordination (ataxia). In some cases, some people could develop recurrent bacterial infections.

Scientific research shows that glutathione levels can tell how long HIV patients are able to survive, or how well and the side effects cancer patients can tolerate chemotherapy and radiation.

Glutathione Deficiency Causes & Treatment

Glutathione deficiency is a major concern. In understanding glutathione deficiency, you will be in a better position to rectify the problem.Here is the major cause:

Gene mutation

Mutation in the GSS gene has been found to cause glutathione deficiency. The GSS gene provides commands to synthesize an enzyme called glutathione synthetase. This enzyme is involved in a series of process called gamma-glutamyl cycle. This cycle enhances the production of glutathione molecule. Glutathione is called an antioxidant because of its role in protecting cells from being damaged by unstable molecules. Gene mutation prevents cells from making sufficient glutathione.

How people inherit glutathione synthetase deficiency

Glutathione synthetase deficiency is inherited in an autosomal recessive pattern, meaning that the mutant gene is located on an autosome, two copies of the gene from each parent are required to be born with the disorder. Usually, the parents are not affected by the disorder.

Glutathione synthetase treatment

Treatment of individuals who have been diagnosed with glutathione synthetase involves providing supplements to rectify the metabolic acidosis and supplying antioxidants such as vitamin E and C.

Oral medication involves a combination of sodium citrate and citric acid (Bicitra). This can maintain plasma bicarbonate levels within reference range.

NAC (N-acetylcysteine) can also be used to treat patients with glutathione synthetase deficiency. It is believed to increase the low intracellular glutathione concentrations and cysteine availability in the white blood cells of patients with this disorder.

Glutathione Deficiency-Bacterial Infections

Glutathione Deficiency Symptoms

Glutathione deficiency symptoms are dependent on the severity of certain diseases. They include:

Hemolytic Anemia

It is caused by mild cases of glutathione synthetase deficiency that results in the destruction of red blood cells. This disease is characterized by chills, dark urine, fatigue and rapid heartbeat.

Urinary excretions

If you are experiencing the excretion of 5-oxoproline in your urine, this could be an indication of glutathione synthetase deficiency. 5-oxoproline is an amino acid also known as pyroglutamic acid builds up in blood when glutathione molecule is not inappropriately processed in the cells.

Metabolic acidosis

This is a condition when there is too much acid in body fluids. If your blood sample test depicts such a case then, you are probably suffering from glutathione synthetase deficiency.

Experiencing neurological disorders

If you are having symptoms such as: seizures, general slowing down of the physical reactions, movements and speech (psychomotor retardation), intellectual disability and loss of coordination (ataxia), you could be having the glutathione deficiency disorder.

Bacterial infection

In some cases, some people who develop recurrent bacterial infections are most likely to suffer from glutathione synthetase deficiency.

Glutathione Dosage- How much Glutathione should I take?


How is glutathione taken and in what forms is it taken?

Glutathione can be taken by oral administration/mouth, in pill form, through inhaling directly to the lungs or via intravenous injection. Documented research has shown that glutathione pills are highly used particularly by women in Asia-Japan to not only improve their skin complexion but also have a radiant glowing skin. It was found out that, usage of pills were safe with minimal side effects. When taking glutathione via intravenous injection, you need to visit a specialist/dermatologist to have the procedure done. It’s advisable to desist from self medication; it could be disastrous to your health.

Recommended Daily dosage for adults and Children

If you visit a physician, the likely recommendations will be through intravenous IV injection .usually for cancer patients, the injection is coupled along with chemicals treatment (chemotherapy) to reduce some of the unwanted side effects of the chemotherapy. Oral administration takes longer time to be absorbed in the body, injection is directly shot in the muscle and tissues. This is preferred as the most effective way of administration. Limited research has been carried on the appropriate daily dosage for children and adults.

As an antioxidant, glutathione recommended dosage is between 10 and 20 mg per body weight. However, you should visit your physician in case of doubt.

Glutathione Dosage for Skin Whitening

If you are considering taking glutathione for skin whitening, you should be conversant with the dosage.

Glutathione consumption as a skin lightening should be between 20 to 40mg per kg of body weight. You are advised to take along with vitamin C for maximum result.

More interesting information on Glutathione

  1. Glutathione Foods- Food High in Glutathione & Natural Sources
  2. What is Glutathione used for and what does it do for Skin, Liver & Body? Products & Where to Buy
  3. Glutathione Side Effects-Is Glutathione Safe? Supplement, Whitening Pills, Soap & Cream Side Effects
  4. Glutathione Benefits for Skin, Cancer, Nasal Spray, Autism, Health, diabetes, Liver & Anti aging

Sources and references

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