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How long does Clonazepam (Klonopin) stay in your System

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How long does clonazepam stay in your system is one the most sought questions when it comes to anxiety tablet.

Research shows that anxiety disorders are among the most distressing conditions that affect people. They are likely to disrupt your normal daily activities. They give you many symptoms that include irritability and fear.

To get rid of this therefore, you ought to seek medical intervention. Clonazepam is one such medications that your doctor can prescribe. Read on to find more about klonopin, the duration it will last in you blood, saliva and urine and tips to get it out fast

What is Clonazepam and how does it work

What it is

This is a medication that is formulated, prescribed and given as a tablet. On the shelves, it is found under the brand name klonopin. It belongs to the group of drugs called benzodiazepines that affect the chemical components of your brain.[1]

How long does clonazepam stay in your system

Clonazepam tablets

What it is popularly known/used for?

This drug is used to treat seizure disorders as well as anxiety disorders. It is in most cases used for the seizures and thus the name an anticonvulsant or antiepileptic drug. This medication is used alongside others and thus known as a combination therapy.

How long does it work?

When you use this drug for the various disorders of the brain, it is good to know how long it takes to work. Before that, it is also good that you become aware of how it works or simply put; the mechanisms of action.

 

This drug mainly depresses your brain. It works through some brain messengers called neurotransmitters known as gamma aminobutyric acid (GABA). Inadequate amounts of the messenger mean that your brain remains excited and thus the witnessed states of seizures and panic. Your doctor should be able to prescribe the best dosage. Being a drug that affects your brain, do not use the drug without a prescription.[2]

How long does klonopin stay in your system, blood, saliva, urine etc

Drugs in your body are eliminated through various means. They can be eliminated through the urine, saliva and sweat. The length of time or how long this drug could stay in your system is measured in terms of half-life. The half-life of clonazepam is between 18 to 50 hours. This however depends on a number of factors that are mainly metabolic. This implies that the amount of the drug divides by half in your system after every 18 to 50 hours. These are reviews from some users on drugs.com.

There are some users who indicate that it could take longer for the drug to be eliminated from your body. Some people project that it could take about 34 hours to eliminate the drug from your body. It is also likely that the drug could stay in your urine for an extra two days to the projected number of days.

All in all, the number of days this drug stays in your body means that it is a long acting drug. There are other times when the drug could even take longer in your system than you expect. Always talk to your doctor if you show any signs that are unusual.

Factors that will determine how long it will last

There are many variables that determine how long the clonazepam will remain in your system. In most cases, the drug is wiped out from your system after about 14 days once you stop using it. There are factors that would make this period longer or shorter.

Amount- 0.5mg klonopin, 2mg of klonopin

You can take clonazepam in different doses depending on various factors. The doses are 0.5mg, 2mg, 0.25mg and 0.125mg.

05-2-mg-klonopin

2mg klonopin

The amount or dosage of this drug determines how fast or how long it takes to excrete it. If you take about 0.5mg of this drug, it will take a shorter time to have it eliminated from your body. In the case of higher doses, a larger content of the drugs goes through metabolism in the liver and thus less breakdown.

The reduction of metabolic efficiency in breakdown leads to an increase in the elimination half-life. When the dose is low, 0.5mg, the liver enzymes are not overworked and thus able to metabolize efficiently. The smaller doses are able to assure the maximum functioning of your liver.

When there is a higher dose, it means that the amount of drug that circulates in your system is greater. If your dose is about 2mg, then the drug will take longer to be eliminated from your system. Larger doses slow down the functioning of your liver. This is based on various reviews by users on drugs.com website.

Other factors

Individual factors

A dose of 1mg could last a different time in your system as compared to another person. The individual factors that account for the differences include the differences in age, genetic variation, differences in liver function and the differences in the mass of the body.

  • Looking at age, the elderly people would take a longer time to clear these drugs as compared to the young. There is a study which points out that the half-life of the clonazepam if you are over 65 years is about 1.8 hours.[3]
  • There is an article that indicates that there is a reduction by 22% clearance of the clonazepam as you age. The delayed clearance is based on various factors that include reduced amount of plasma proteins, decrease in the liver function and decreased blood flow.
  • Body mass and fat. If you have a greater mass (height/weight) as compared to the dosage of the drug, then you should be in a position to excrete the drug within the shortest time possible. The other thing your doctor will look into so as to give you a medication is the mass to fat ratio. This drug is known to be fat loving and thus likely to stick in the fat compartments of your body. This therefore means that if you have more fat, then you will retain the drug longer than a person with lower fat content.
  • Body metabolic rate. If you have a higher body metabolic rate, then you will metabolize the drug at a faster rate compared to if you have a lower body metabolic rate. When you are at rest and thus higher body metabolic rate, your body expends more energy and thus you break down more drug.
  • Genetic variation dictates how fast or slow you metabolize and excrete clonazepam. This drug is broken down by some enzymes that are called CYO3A4 that are found in your liver. There is likely to be a variation from one person to another. They therefore determine how fast or slow you metabolize the drug. If you metabolize the drug poorly, you will have it retained in your system longer.
  • Liver function. If you have a problem or an impairment of your liver, then you will have a challenge to break down the drug. This is because any impairment in your liver affects the function of the enzyme CYP3A4 that is in charge of metabolism. This is more evident if you have a condition called liver cirrhosis. In this case for example, the clearance of the drug is greatly affected.
  • The intake of food. If you take klonopin alongside food, then you will have it take a longer time to be absorbed. The type and amount of meal that you take could also affect the absorption. If you take a meal and then take the drug, the time you take to eliminate it would be more than if you take it on an empty stomach.
  • Urinary pH. This greatly influences how fast and how much of the drug you are able to eliminate from your body. A low pH with a characteristic acidic urine is likely to witness a higher clearance of this drug. This therefore means that acidic urine enhances the elimination of clonazepam.

Administration of the drug with other drugs.

When you take the clonazepam with other drugs, it is likely to affect the elimination of the drug. The drugs that affect the liver enzyme CYP3A4 go a long way to affect the breakdown of the drug.

There are drugs that are known as inhibitors which limit the functioning of clonazepam and thus increase their amount in the system.

On the other hand, there are drugs that are called inducers. They are able to facilitate faster breakdown of clonazepam and thus able to increase their elimination.

The terms of administration

The time and length you take the drug determines how long it takes for you to get rid of it from your system. If you take clonazepam consistently for as long as a year, then you are likely to have increased half-life of elimination from your system. This is unlike someone who has taken the drug for fewer number of days.

Because of the lipid loving nature of the drug, it will interact well with the lipid compartments and thus accumulate in your tissues. If you take it for a day or two, it is unlikely that the drug will reach steady state concentration. The steady state is reached upon 5 to 7 days of consistent dosing.

How to get klonopin out of your system fast

There are things you could do or your doctor will do so as to facilitate faster removal of clonazepam from your system. This is an attempt to prevent likely toxicity or harmful effects of the drug.

What are the effects of it staying in your system

There are effects that would come as a result of the clonazepam staying in your system for a longer period of time. They include:

  • Respiratory depression
  • Depression of the central nervous system
  • Outbreak of seizures
  • Rashes and hives on your skin

How to get it out

Burn excess fats. Clonazepam is able to stick to fat molecules in your body. Having less fat deposits is associated with fast elimination. The best way to burn the fats from your body is always through physical exercise.

burn fat to get clonazepam out fast

Get rid of excess fat

Activated charcoal. This is one of the best remedies you can use at home to rid your system of the clonazepam. It is useful because it could detoxify your system. The stoppage of clonazepam use does not guarantee safety because it has a long half-life. This is a very useful heath supplement that you can ever think of because it adsorbs some of the drugs to facilitate their removal.

Acidification. This is very contrary to most other drugs. It has been shown that acidification is an effective method to get rid of clonazepam from your system. To acidify your body, you take foods like cranberry and other acidifying foods.

Hydration. If you effectively hydrate your body using water, you will increase the rate of urination. This in the long run is able to get the drug out of your system faster. The pH of your urine reduces and the output of the urine becomes great.

Sources

[1] https://www.drugs.com/clonazepam.html

[2] https://www.healthline.com/health/clonazepam-oral-tablet#highlights1

[3] http://www.ncbi.nlm.nih.gov/pubmed/36252

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